The Mathematics and Biology of the Biodistribution of Radiopharmaceuticals - A Clinical Perspective

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The Mathematics and Biology of the Biodistribution of Radiopharmaceuticals: A Clinical Perspective uses mathematic equations to describe the distribution of radiopharmaceuticals. The mathematics provide a conceptual basis for the biodistribution of the radiopharmaceutical.

Radionuclide Production for Nuclear Medicine

By the end of the book, readers better understand that visual assessment of images in nuclear medicine can be further clarified and explained by numbers. The book is divided into 3 parts, and its primary focus is to use mathematics to explain the biologic and physiologic processes that influence the biodistribution of radiopharmaceuticals depicted in the images. Part I provides a historical background to the field of nuclear medicine and discusses two ways to evaluate images: visual versus quantitative interpretation.

Here, the author points out that quantitation can enhance interpretation of images and is most effective when used together with visual interpretation. Again, the author is effective in engaging readers with figures, images, and tables; but it should be noted that Table 2. Part II dives into the mathematics that explain the biologic processes influencing biodistribution of the imaging agent.

Although therapeutic procedures are not discussed in this book, it is stated that the concepts of the equations for diagnostic studies will also apply to corresponding therapeutic radiopharmaceuticals. The author presents elaborate equations to explain, conceptually, what is happening in the body with the drug that is being captured in the image.

Each chapter introduces different equations that relate to nuclear medicine studies, such as clearance, central volume principal, first-circulation time—activity curves, convolution analysis, measurement of relative and absolute function, and lastly a section on other quantitative techniques.

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William C. Klingensmith III, M.

Then he returned to the University of Colorado School of Medicine as the head of nuclear medicine for seven years. He then joined Radiology Imaging Associates, a large academically oriented private practice radiology group in Denver.


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After 25 years in private practice he returned to the University of Colorado School of Medicine to again head nuclear medicine. Klingensmith has had an interest in the mathematics and biology of radiopharmaceutical localization throughout his career. During his nuclear medicine fellowship he determined the information content of first circulation time-activity curves.

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The Mathematics and Biology of the Biodistribution of Radiopharmaceuticals: A Clinical Perspective

More recently he developed the clinically oriented equation for clearance of a radiopharmaceutical from blood into tissue, and the general algorithm for determining whether a physiologic measurement needs to be normalized for body size. Le, Journal of Nuclear Medicine, February, This particular approach makes the book extremely useful ….


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Quantitative Evaluation in Nuclear Medicine Studies. Radiopharmaceuticals and Their Associated Studies.

Computational Study of Radiopharmaceuticals

Tables of Extraction Mechanisms and Corresponding Studies. Distribution of Cardiac Output in the Body at Rest. The Mathematics and Biology of the Biodistribution of Radiopharmaceuticals Mathematics of the Biodistribution of Radiopharmaceuticals.